|Calculated MW||11.5 kDa|
|Other Names||Melanoma inhibitory activity protein 2, Melanoma inhibitory activity protein 2|
|Sequence||MLESTKLLAD LKKCGDLECE ALINRVSAMR DYRGPDCRYL NFTKGEEISV YVKLAGERED LWAGSKGKEF GYFPRDAVQI EEVFISEEIQ MSTKESDFLC L|
|Application Notes||Reconstitute in sterile H₂O at >100 µg/ml. Reconstituted MIA2 should be stored in working aliquots at -20°C.|
|Storage||-20°C; Sterile filtered white powder lyophilized from a solution containing 20 mM phosphate buffer pH 7.4 and 150 mM NaCl.|
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MIA2 performs as a tumour suppressor in hepatocellular carcinoma. MIA2 is a novel acute phase protein which its expression is found in the liver and reacts to liver damage in chronic liver diseases and is considerably higher in severe fibrosis patients . MIA2 is induced by IL6, TGF- and conditioned medium from activated hepatic stellate cells. MIA2 is is mainly expressed in hepatocytes. MIA2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain consisting of 101 amino having a total molecular mass of 11.5 kDa. The MIA2 is purified by proprietary chromatographic techniques.
Bosserhoff A.K.,et al.J. Biol. Chem. 278:15225-15231(2003).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Sjoeblom T.,et al.Science 314:268-274(2006).
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