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Vaspin, human recombinant protein
Serpin A12 precursor, Visceral adipose-specific serpin, Visceral adipose tissue- derived serine prot
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IW75 |
|---|---|
| Concentration | 1 |
| Calculated MW | 47.0 kDa |
| Gene ID | 145264 |
|---|---|
| Gene Symbol | SPA12 |
| Other Names | Serpin A12 precursor, Visceral adipose-specific serpin, Visceral adipose tissue- derived serine protease inhibitor, Vaspin, OL-64, SERPINA12, Serine (or cysteine) proteinase inhibitor, clade A, antitrypsin, α-1 antiproteinase, |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥90% |
| Recombinant | Yes |
| Application Notes | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized from 50 mM Tris, pH 7.5 + 150 mM NaCl. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, is a member of serine protease inhibitor family. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. Recombinant human Vaspin produced in E.Coli is a single, non-glycosylated polypeptide chain containing 415 amino acids and having a molecular mass of 47 kDa.
References
Hida K.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:10610-10615(2005).
Chen S.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
Heiker J.T.,et al.Cell. Mol. Life Sci. 70:2569-2583(2013).
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