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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   TGF-β1 Blocking Peptide   

TGF-β1 Blocking Peptide

Product Information
Primary Accession P01137
Gene ID 7040
Calculated MW 44341 Da
Additional Information
Gene ID 7040
Application & Usage The peptide is used for blocking the antibody activity of TGF-β1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB
Target/Specificity TGF-β1
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsTGF-β1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGFB1
Synonyms TGFB
Function Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.
Research Areas
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$ 95.00
Cat# PBV10491b
(40 western blots)
Availability: 5-7days
Bulk Size
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