|Calculated MW||12367 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of DAP-12. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KAR-associated protein, Tyrobp, Dap12, Karap|
|Formulation||50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||DAP12 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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