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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   BMP-14 Blocking Peptide   

BMP-14 Blocking Peptide

Product Information
Primary Accession P43026
Other Accession EAW76208
Gene ID 8200
Calculated MW 55411 Da
Additional Information
Gene ID 8200
Application & Usage The peptide is used for blocking the antibody activity of active BMP-14. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C
Other Names Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, BMP-14, Cartilage-derived morphogenetic protein 1, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, LPS-associated protein 4, Radotermin, GDF5, BMP14, CDMP1
Target/Specificity BMP-14
Formulation 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsBMP-14 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF5
Synonyms BMP14, CDMP1
Function Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
Cellular Location Secreted. Cell membrane
Tissue Location Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level)
Research Areas
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$ 95.00
Cat# PBV10494b
(40 western blots)
Availability: 5-7days
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