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SUMO3, human recombinant protein


Product info
Calculated MW 11.6 kDa
Additional Info
Gene Symbol SUMO3
Other Names SUMO3; SMT3A; SMT3H1; SUMO-3, SMT3 homolog 1, SUMO-2, Ubiquitin-like protein SMT3B
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Results 10-50 µM
Format Liquid
Storage -80°C; In 50 mM HEPES, pH 8.0, plus 150 mM NaCl, 1 mM DTT.
Citations (0)

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SUMO modification has been implicated in functions such as nuclear transport, chromosome segregation and transcriptional regulation. SUMO functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. Still, unlike ubiquitin which targets proteins for degradation, SUMO is involved in a variety of Cellular processes, for example nuclear transport, transcriptional regulation, apoptosis, and protein stability. The active recombinant SUMO-3 is derived from the precursor pro-SUMO-3 (Accession # NM_006936). Human SUMO-3 shares 47% and 87% identity with SUMO-1 and SUMO-2 respectively. SUMOylation can occur without the requirement of a specific E3 ligase activity, where SUMO is transferred directly from UbcH9 to specific substrates. SUMOylated substrates are primarily localized to the nucleus (RanGAP-1, RANBP2, PML, p53, Sp100, HIPK2) but there are also cytosolic substrates (IκBα, GLUT1, GLUT4). SUMO modification has been implicated in functions such as nuclear transport, chromosome segregation, transcriptional regulation, apoptosis and protein stability.

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$ 185.00
$ 1,350.00
Cat# PBV10506r
(40 western blots)
Availability: 5-7days
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