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EDEM2 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BV94 |
|---|---|
| Gene ID | 55741 |
| Calculated MW | 64753 Da |
| Gene ID | 55741 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of EDEM2. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
| Other Names | ER degradation-enhancing alpha-mannosidase-like protein 2, EDEM2, C20orf31, C20orf49 |
| Target/Specificity | EDEM2 |
| Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | EDEM2 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EDEM2 |
|---|---|
| Synonyms | C20orf31, C20orf49 |
| Function | Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity). |
| Cellular Location | Endoplasmic reticulum lumen |
| Tissue Location | Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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