|Calculated MW||43201 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of PSGL-1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||P-selectin glycoprotein ligand 1, PSGL-1, Selectin P ligand, CD162, SELPLG|
|Formulation||50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||PSGL-1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on neutrophils, monocytes and most lymphocytes|
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