Prolactin Receptor, human recombinant protein
PRL-R, hPRLrI, PRL, luteotropic hormone, LTH, PRLR, PRL-R, PRL R
|Calculated MW||23.97 kDa|
|Other Names||PRL-R, hPRLrI, PRL, luteotropic hormone, LTH, PRLR, PRL-R, PRL R|
|Application Notes||Reconstitute in sterile dH₂O to a concentration of 0.1 -1 mg/ml and let the lyophilized pellet dissolve completely. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.|
|Storage||-20°C; Lyophilized from a concentrated (0.4 mg/ml) solution with 0.0045 mM NaHCO₃|
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Provided below are standard protocols that you may find useful for product applications.
Prolactin is a pituitary hormone that plays a role in the stimulation of milk production, salt and H₂O regulation, growth, development and reproduction. The primary step in its action is the binding to a specific membrane receptor (prolactin receptor) which belongs to the superfamily of class 1 cytokine receptors. Prolactin is a hormone involved in a range of significant functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions. Prolactin exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane Prolactin receptor. PRLR varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. Recombinant human Prolactin Receptor (Extra Cellular Domain) produced in E.Coli is a non-glycosylated, Polypeptide chain containing 210 amino acids and having a molecular mass of 23.97 kDa.
Boutin J.-M.,et al.Mol. Endocrinol. 3:1455-1461(1989).
Kline J.B.,et al.J. Biol. Chem. 274:35461-35468(1999).
Hu Z.-Z.,et al.J. Clin. Endocrinol. Metab. 84:1153-1156(1999).
Hu Z.Z.,et al.J. Biol. Chem. 276:41086-41094(2001).
Kline J.B.,et al.Mol. Endocrinol. 16:2310-2322(2002).
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