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Human recombinant protein UCHL1

Human Recombinant UCHL1

     
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Product info
Primary Accession P09936
Concentration 1
Calculated MW 24.8 kDa (223 aa)
Additional Info
Gene ID 7345
Gene Symbol UCHL1
Other Names Ubiquitin carboxyl-terminal esterase L1, UCHL1, PARK5, Uch-L1, PGP9.5.
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE TEKMSPEDRA KCFEKNEAIQ AAHDAVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP FPVNHGASSE DTLLKDAAKV CREFTEREQG EVRFSAVALC KAA
Format Liquid
Storage -80°C; 1 mg/ml solution in In 20 mM Tris-HCl buffer (pH 8.0) containing 2 mM EDTA.
Citations (0)

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Background

PGP9.5/UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. PGP9.5 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. PGP9.5 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Recombinant PGP9.5 protein was expressed in E.coli and purified by using conventional chromatography techniques.

References

Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Day I.N.M.,et al.Biochem. J. 268:521-524(1990).
Choi J.,et al.J. Biol. Chem. 279:13256-13264(2004).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.

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$ 315.00
Cat# PBV10545r
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