|Calculated MW||14.2 kDa|
|Other Names||Peptidyl-prolyl cis-trans isomerase FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase|
|Sequence||MGSSHHHHHH SSGLVPRGSH RSMGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE|
|Storage||-80°C; 0.25 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 20% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) belongs to the immunophilin protein family which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1B is a cis-trans prolyl isomerase which binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). FKBP1B is extremely similar to the FK506-binding protein 1A. The physiological role of FKBP1B is thought to be in excitation-contraction coupling in cardiac muscle.
Arakawa H.,et al.Biochem. Biophys. Res. Commun. 200:836-843(1994).
Lam E.,et al.J. Biol. Chem. 270:26511-26522(1995).
Seidler T.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Nakazawa T.,et al.Gene 360:55-64(2005).
Hillier L.W.,et al.Nature 434:724-731(2005).
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