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Human recombinant protein FKBP1B

Human Recombinant FKBP1B

     
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Product info
Primary Accession P68106
Concentration 0.25
Calculated MW 14.2 kDa
Additional Info
Gene ID 2281
Gene Symbol FKBP1B
Other Names Peptidyl-prolyl cis-trans isomerase FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase
Gene Source Human
Source E. Coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MGSSHHHHHH SSGLVPRGSH RSMGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE
Format Liquid
Storage -80°C; 0.25 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 20% glycerol.
Citations (0)

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Background

Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) belongs to the immunophilin protein family which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1B is a cis-trans prolyl isomerase which binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). FKBP1B is extremely similar to the FK506-binding protein 1A. The physiological role of FKBP1B is thought to be in excitation-contraction coupling in cardiac muscle.

References

Arakawa H.,et al.Biochem. Biophys. Res. Commun. 200:836-843(1994).
Lam E.,et al.J. Biol. Chem. 270:26511-26522(1995).
Seidler T.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Nakazawa T.,et al.Gene 360:55-64(2005).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 340.00
Cat# PBV10578r
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