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Human recombinant protein FKBP3

Human Recombinant FKBP3

     
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Product info
Primary Accession Q00688
Concentration 1
Calculated MW 25.1 kDa
Additional Info
Gene ID 2287
Gene Symbol FKBP3
Other Names FK506 binding protein 3, FKBP25, PPIase FKBP3, Rotamase
Gene Source Human
Source E. Coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID
Format Liquid
Storage -80°C; 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.
Citations (0)
citation

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Background

FKBP3 is part of a family of immunosuppressant receptors which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 accelerates the folding of proteins. FKBP3 is part of the immunophilin protein family, which participates in immunoregulation and fundamental cellular processes concerning protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a greater affinity for rapamycin than for FK506 and therefore is a significant protein for immunosuppression by rapamycin.

References

Wiederrecht G.,et al.Biochem. Biophys. Res. Commun. 185:298-303(1992).
Hung D.T.,et al.Biochem. Biophys. Res. Commun. 184:733-738(1992).
Jin Y.-J.,et al.J. Biol. Chem. 267:10942-10945(1992).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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Discontinued
Cat# PBV10579r-100
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