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Superoxide Dismutase 2 (SOD-2), human recombinant protein
Human Recombinant SOD2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04179 |
|---|---|
| Concentration | 0.5 |
| Calculated MW | 24.4 kDa (219 aa, 25-222 aa + His Tag) |
| Gene ID | 6648 |
|---|---|
| Gene Symbol | SOD2 |
| Other Names | Superoxide dismutase [Mn], mitochondrial, IPOB, MNSOD, MVCD6. |
| Gene Source | Human |
| Source | E. Coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | >1,200 units/mg |
| Sequence | MGSSHHHHHH SSGLVPRGSH MKHSLPDLPY DYGALEPHIN AQIMQLHHSK HHAAYVNNLN VTEEKYQEAL AKGDVTAQIA LQPALKFNGG GHINHSIFWT NLSPNGGGEP KGELLEAIKR DFGSFDKFKE KLTAASVGVQ GSGWGWLGFN KERGHLQIAA CPNQDPLQGT TGLIPLLGID VWEHAYYLQY KNVRPDYLKA IWNVINWENV TERYMACKK |
| Format | Liquid |
| Storage | -80°C; 0.5 mg/ml solution in 20 mM Tris-HCl (pH 8.0) containing 20% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SOD2 is part of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. SOD2 destroys radicals which are usually produced within the cells and which are toxic to biological systems.
References
Wispe J.R.,et al.Biochim. Biophys. Acta 994:30-36(1989).
Beck Y.,et al.Nucleic Acids Res. 15:9076-9076(1987).
Heckl K.,et al.Nucleic Acids Res. 16:6224-6224(1988).
Ho Y.-S.,et al.FEBS Lett. 229:256-260(1988).
Church S.L.,et al.Biochim. Biophys. Acta 1087:250-252(1990).
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