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Human recombinant protein DUSP3

Human Recombinant DUSP3

     
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Product info
Primary Accession P51452
Concentration 1
Calculated MW 22.6 kDa (205 aa, 1-185 aa + NT His-Tag)
Additional Info
Gene ID 1845
Gene Symbol DUSP3
Other Names Dual specificity protein phosphatase 3, VHR.
Gene Source Human
Source E. Coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results >1750 units/mg
Sequence MGSSHHHHHH SSGLVPRGSH MSGSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVTPRIYVG NASVAQDIPK LQKLGITHVL NAAEGRSFMH VNTNANFYKD SGITYLGIKA NDTQEFNLSA YFERAADFID QALAQKNGRV LVHCREGYSR SPTLVIAYLM MRQKMDVKSA LSIVRQNREI GPNDGFLAQL CQLNDRLAKE GKLKP
Format Liquid
Storage -80°C; 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2 mM DTT and 0.15 M NaCl.
Citations (0)

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Background

DUSP3 belongs to the dual specificity protein phosphatase subfamily which inactivates their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSP3 negatively regulate members of the mitogen-activated protein kinase superfamily that are related to cellular proliferation and differentiation. DUSP3 is expressed in both breast and ovarian tissues and displays activity both for tyrosine-protein phosphate and serine-protein phosphate, but exhibits a strong preference toward phosphotyrosines, specifically dephosphorylates and inactivates ERK1 and ERK2.

References

Ishibashi T.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:12170-12174(1992).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Todd J.L.,et al.J. Biol. Chem. 274:13271-13280(1999).

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$ 340.00
Cat# PBV10607r-100
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