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K63-linked Tetra-Ubiquitin recombinant protein

K63-linked Tetra-Ubiquitin

Product info
Concentration 2.5
Calculated MW 34.233 kDa (Band migrates faster on gels)
Additional Info
Assay&Purity Western Blot; ≥95%
Assay2&Purity2 N/A;
Format Liquid
Storage -80°C; 2.5 mg/ml in 20 mM Tris-HCl, pH 7.5, 0.15 M NaCl and 1 mM EDTA.
Citations (0)

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Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. Modification of proteins by K63-linked polyubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, and neurodegeneration. These tetra-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for a lysine at position 63, limiting the chain length.

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$ 295.00
Cat# PBV10653r
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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