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>   home   >   Products   >   Proteins   >   Human recombinant protein Ubiquitin Activating Enzyme E1   

Human recombinant protein Ubiquitin Activating Enzyme E1

Human recombinant Ubiquitin Activating Enzyme E1

Product info
Primary Accession P22314
Calculated MW 118 kDa
Additional Info
Gene ID 7317
Gene Symbol UBA1
Other Names UBE1, UBA1, POC20, A1S9T, A1ST, AMCX1, GXP1, SMAX2
Gene Source Human
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Format Liquid
Storage -80°C; In 50 mM Tris (pH 8.0), 100 mM NaCl and 10% glycerol.
Citations (0)

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UBE1, the ubiquitin activating enzyme, is the first enzyme utilized in the pathway to conjugate ubiquitin onto target substrates through an ubiquitin-protein isopeptide bond. The C-terminal glycine of an ubiquitin (G76) is initially adenylated in an ATP dependent manner activating it so it can be transferred to the active site cysteine of UBE1 forming an ubiquitin-UBE1 thiolester. With the help of the other enzymes in the ubiquitin conjugation pathway (E2/E3 enzymes) the ubiquitin is transferred to a specific lysine on a target substrate.


Ayusawa D.,et al.Cell Struct. Funct. 17:113-122(1992).
Handley P.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:258-262(1991).
Handley P.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:7456-7456(1991).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 335.00
Cat# PBV10661r-50
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