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Human recombinant protein UBE2K

Human recombinant UBE2K

Product info
Primary Accession P61086
Calculated MW 22.406 kDa
Additional Info
Gene ID 3093
Gene Symbol UBE2K
Other Names HIP2, Huntingtin Interacting protein 2, HYPG, Ubiquitin-conjugating enzyme E2-25K kDa, Ubiquitin-protein ligase, Ubiquitin carrier protein, LIG, HIP-2, E2 (25K), DKFZp686J24237, EC
Gene Source Human
Assay&Purity RP-HPLC; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Format Liquid
Storage -80°C; 75 µL of a 40 µM solution (3 nmoles) in TBS.
Citations (0)

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UBE2K, also known as UbcH1 or E2-25K, is an E2 (ubiquitin conjugating enzyme) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E3 enzymes. Once an E1 is carrying an activated ubiquitin in a ubiquitin-E1 thiolester complex, this activated ubiquitin is transferred to the active site cysteine of the E2 to form a ubiquitin-E2 thiolester complex. With the aid of an E3, the activated ubiquitin is then targeted to a specific substrate lysine. UBE2K is a biochemically important E2 due to its ability to form free K48-linked polyubiquitin chains in solution in the absence of an E3. This ability is attributed to UbcH1 possessing a C-terminal UBA domain, in addition to its E2 catalytic domain. UBE2K takes part in many cellular processes such as selective protein degradation, DNA repair, cell cycle control, and sporulation. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with amyloid-β, Huntington, and MHC-heavy chain proteins.


Kalchman M.A.,et al.J. Biol. Chem. 271:19385-19394(1996).
Kikuchi J.,et al.Arterioscler. Thromb. Vasc. Biol. 20:128-134(2000).
Furukawa Y.,et al.Electrophoresis 21:338-346(2000).
Li W.B.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 315.00
Cat# PBV10664r-3
Availability: 5-7days
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