|Calculated MW||34 kDa, homodimer, glycosylated.|
|Other Names||BMP4, ZYME, BMP2B, BMP2B1|
|Source||Human 293 cell expressed|
|Results||2 to 10 ng/ml|
|Application Notes||Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a PBS solution.|
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Provided below are standard protocols that you may find useful for product applications.
BMP4 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-4 plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
Wozney J.M.,et al.Science 242:1528-1534(1988).
Shore E.M.,et al.Calcif. Tissue Int. 63:221-229(1998).
Oida S.,et al.DNA Seq. 5:273-275(1995).
Yanagita M.,et al.Biochem. Biophys. Res. Commun. 316:490-500(2004).
Felder B.,et al.Eur. J. Hum. Genet. 10:753-756(2002).
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