Human CellExp FGF-2/FGF-basic, Human recombinant protein
Human Cellexp Human Recombinant FGF-basic
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P09038 |
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Calculated MW | 17 kDa, monomer, non-glycosylated |
Gene ID | 2247 |
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Gene Symbol | FGF2 |
Other Names | Prostatropin, HBGH-2, HBGF-2, FGF-2, FGF-b. |
Gene Source | Human |
Source | Human cell expressed |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Results | 0.1 to 0.5 ng/ml |
Application Notes | Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin. |
Format | Lyophilized |
Storage | -80°C; Lyophilized from a PBS solution. |
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Provided below are standard protocols that you may find useful for product applications.
Background
FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.
References
Abraham J.A.,et al.Cold Spring Harb. Symp. Quant. Biol. 51:657-668(1986).
Abraham J.A.,et al.EMBO J. 5:2523-2528(1986).
Prats H.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:1836-1840(1989).
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
Hillier L.W.,et al.Nature 434:724-731(2005).
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