|Calculated MW||16 kDa, monomer, glycosylated|
|Other Names||Leukocyte interferon, B cell interferon, Type I interferon, IFNA2, IFN-α 2a.|
|Source||Human 293 cell expressed|
|Results||0.02 to 0.08 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a PBS solution.|
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Provided below are standard protocols that you may find useful for product applications.
Interferons (IFNs) are proteins made and released by host cells in response to the presence of pathogens. They belong to the large class of glycoproteins known as cytokines. IFN-alpha is produced by macrophages and has antiviral activities. IFNs also have other functions: they activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes; and they increase the ability of uninfected host cells to resist new infection by virus.
Goeddel D.V.,et al.Nature 287:411-416(1980).
Goeddel D.V.,et al.Nature 290:20-26(1981).
Lawn R.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 78:5435-5439(1981).
Oliver G.,et al.Rev. Latinoam. Microbiol. 27:141-150(1985).
Austruy E.,et al.Cancer Gene Ther. 5:247-256(1998).
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