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Human CellExp IL-1beta, Human recombinant protein
Human Cellexp Human Recombinant IL-1beta
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01584 |
|---|---|
| Calculated MW | 18 and 25 kDa, monomer, glycosylated |
| Gene ID | 3553 |
|---|---|
| Gene Symbol | IL1B |
| Other Names | Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF), IL1F2, IL-1 beta. |
| Gene Source | Human |
| Source | Human 293 cell expressed |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | 0.02 to 0.08 ng/ml |
| Application Notes | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| Format | Lyophilized |
| Storage | -80°C; Lyophilized from a PBS solution. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Interleukin-1beta is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL1beta proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. In comparison with the E. coli expressed protein, IL-1 beta is 50% more potent in promoting human CD4+ T cell differentiation into Th17 cells. This cytokine is produced in a serumfree, chemically defined media.
References
Auron P.E.,et al.Proc. Natl. Acad. Sci. U.S.A. 81:7907-7911(1984).
March C.J.,et al.Nature 315:641-647(1985).
Clark B.D.,et al.Nucleic Acids Res. 14:7897-7914(1986).
Clark B.D.,et al.Nucleic Acids Res. 15:868-868(1987).
Nishida T.,et al.Biochem. Biophys. Res. Commun. 143:345-352(1987).
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