Human CellExp IL-2, Human recombinant protein
Human Cellexp Human Recombinant IL-2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P60568 |
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Calculated MW | 15 kDa, monomer, glycosylated |
Gene ID | 3558 |
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Gene Symbol | IL2 |
Other Names | T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2. |
Gene Source | Human |
Source | Human 293 cell expressed |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Results | 0.2 to 2 ng/ml |
Application Notes | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
Format | Lyophilized |
Storage | -80°C; Lyophilized from a PBS solution. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IL-2 is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses and is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
References
Maeda S.,et al.Biochem. Biophys. Res. Commun. 115:1040-1047(1983).
Taniguchi T.,et al.Nature 302:305-310(1983).
Devos R.,et al.Nucleic Acids Res. 11:4307-4323(1983).
Fujita T.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:7437-7441(1983).
Holbrook N.J.,et al.Nucleic Acids Res. 12:5005-5013(1984).
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