|Calculated MW||15 kDa, monomer, glycosylated|
|Other Names||T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.|
|Source||Human 293 cell expressed|
|Results||0.2 to 2 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a PBS solution.|
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Provided below are standard protocols that you may find useful for product applications.
IL-2 is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses and is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Maeda S.,et al.Biochem. Biophys. Res. Commun. 115:1040-1047(1983).
Taniguchi T.,et al.Nature 302:305-310(1983).
Devos R.,et al.Nucleic Acids Res. 11:4307-4323(1983).
Fujita T.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:7437-7441(1983).
Holbrook N.J.,et al.Nucleic Acids Res. 12:5005-5013(1984).
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