|Calculated MW||14 and 19 kDa, monomer|
|Other Names||BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra.|
|Source||Human 293 cell expressed|
|Results||0.1 to 0.5 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a solution of 20 mM Tris-HCl, pH 7.4, with 300 mM NaCl.|
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Provided below are standard protocols that you may find useful for product applications.
IL4 is a pleiotropic cytokine and a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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Eder A.,et al.Nucleic Acids Res. 16:772-772(1988).
Carr C.,et al.Biochemistry 30:1515-1523(1991).
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