|Calculated MW||14 and 19 kDa, monomer|
|Other Names||BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra.|
|Source||Human 293 cell expressed|
|Results||0.1 to 0.5 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a solution of 20 mM Tris-HCl, pH 7.4, with 300 mM NaCl.|
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Provided below are standard protocols that you may find useful for product applications.
IL4 is a pleiotropic cytokine and a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Yokota T.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:5894-5898(1986).
Arai N.,et al.J. Immunol. 142:274-282(1989).
Klein S.C.,et al.Immunogenetics 41:57-57(1995).
Eder A.,et al.Nucleic Acids Res. 16:772-772(1988).
Carr C.,et al.Biochemistry 30:1515-1523(1991).
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