Human CellExp IL-10, Human recombinant protein
Human Cellexp Human Recombinant IL-10
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P22301 |
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Calculated MW | 17 kDa, non-disulfide bonded homodimer, glycosylated |
Gene ID | 3586 |
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Gene Symbol | IL10 |
Other Names | B-TCGF, CSIF, TGIF, IL-10, IL10A, MGC126450, MGC126451, Cytokine synthesis inhibitory factor. |
Gene Source | Human |
Source | Human 293 cell expressed |
Assay&Purity | SDS-PAGE; > 95% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Results | 0.3 to 1.5 ng/ml |
Application Notes | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
Format | Lyophilized |
Storage | -80°C; Lyophilized from a PBS solution. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IL10 is produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
References
Vieira P.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1172-1176(1991).
Sanjanwala B.,et al.Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
Dai W.-J.,et al.Haerbin Yi Ke Da Xue Xue Bao 35:4-6(2001).
Gesser B.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:14620-14625(1997).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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