|Calculated MW||17 kDa, non-disulfide bonded homodimer, glycosylated|
|Other Names||B-TCGF, CSIF, TGIF, IL-10, IL10A, MGC126450, MGC126451, Cytokine synthesis inhibitory factor.|
|Source||Human 293 cell expressed|
|Assay&Purity||SDS-PAGE; > 95%|
|Results||0.3 to 1.5 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a PBS solution.|
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Provided below are standard protocols that you may find useful for product applications.
IL10 is produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Vieira P.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1172-1176(1991).
Sanjanwala B.,et al.Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
Dai W.-J.,et al.Haerbin Yi Ke Da Xue Xue Bao 35:4-6(2001).
Gesser B.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:14620-14625(1997).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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