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Human CellExp IL-10, Human recombinant protein

Human Cellexp Human Recombinant IL-10

Product info
Primary Accession P22301
Calculated MW 17 kDa, non-disulfide bonded homodimer, glycosylated
Additional Info
Gene ID 3586
Gene Symbol IL10
Other Names B-TCGF, CSIF, TGIF, IL-10, IL10A, MGC126450, MGC126451, Cytokine synthesis inhibitory factor.
Gene Source Human
Source Human 293 cell expressed
Assay&Purity SDS-PAGE; > 95%
Assay2&Purity2 N/A;
Recombinant Yes
Results 0.3 to 1.5 ng/ml
Application Notes Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Format Lyophilized
Storage -80°C; Lyophilized from a PBS solution.
Citations (0)

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IL10 is produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.


Vieira P.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1172-1176(1991).
Sanjanwala B.,et al.Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
Dai W.-J.,et al.Haerbin Yi Ke Da Xue Xue Bao 35:4-6(2001).
Gesser B.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:14620-14625(1997).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).

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$ 270.00
$ 1,180.00
Cat# PBV10698r
(40 western blots)
Availability: 5-7days
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