|Calculated MW||57 kDa, heterodimer, glycosylated|
|Other Names||NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-alpha, IL-12.|
|Source||Human 293 cell expressed|
|Assay&Purity||SDS-PAGE; > 95%|
|Results||0.1 to 0.5 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a PBS solution.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
IL-12 is a potent regulator of cell mediated immune responses and in induces IFN-Ɣ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B-lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induce the development of IFN-Ɣ producing Th1 cells.
Wolf S.F.,et al.J. Immunol. 146:3074-3081(1991).
Gubler U.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:4143-4147(1991).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Stern A.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:6808-6812(1990).
Merberg D.M.,et al.Immunol. Today 13:77-78(1992).
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