|Calculated MW||57 kDa, heterodimer, glycosylated|
|Other Names||NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-alpha, IL-12.|
|Source||Human 293 cell expressed|
|Assay&Purity||SDS-PAGE; > 95%|
|Results||0.1 to 0.5 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from a PBS solution.|
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Provided below are standard protocols that you may find useful for product applications.
IL-12 is a potent regulator of cell mediated immune responses and in induces IFN-Ɣ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B-lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induce the development of IFN-Ɣ producing Th1 cells.
Wolf S.F.,et al.J. Immunol. 146:3074-3081(1991).
Gubler U.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:4143-4147(1991).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Stern A.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:6808-6812(1990).
Merberg D.M.,et al.Immunol. Today 13:77-78(1992).
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