|Calculated MW||38 kDa, homodimer, glycosylated|
|Other Names||IL17A/F, IL17 A/F, IL-17A/F, IL-17 A/F, IL17AF, IL-17 AF, Interleukin-17 A/F, Interleukin-17 AF.|
|Source||Human 293 cell expressed|
|Assay&Purity||SDS-PAGE; > 95%|
|Results||100 to 500 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized in PBS.|
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Provided below are standard protocols that you may find useful for product applications.
Interleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. IL-17F is a member of the IL-17 family of structurally-related cytokines. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F stimulates proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.
Starnes T.,et al.J. Immunol. 167:4137-4140(2001).
Mungall A.J.,et al.Nature 425:805-811(2003).
Kawaguchi M.,et al.J. Immunol. 167:4430-4435(2001).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
Hymowitz S.G.,et al.EMBO J. 20:5332-5341(2001).
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