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Human CellExp IL-23, Human recombinant protein
Human Cellexp Human Recombinant IL-23
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NPF7 |
|---|---|
| Calculated MW | 55 kDa, heterodimer, glycosylated |
| Gene ID | 51561 |
|---|---|
| Gene Symbol | IL23A |
| Other Names | Interleukin 23 alpha subunit p19, Interleukin-12 subunit beta p40, SGRF, IL23P19, IL-23-A, interleukin-six, G-CSF related factor, JKA3 induced upon T-cell activation, interleukin 12B (natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturation factor 2 p40), NK cell stimulatory factor chain 2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF2, CLMF p40. |
| Gene Source | Human |
| Source | Human 293 cell expressed |
| Assay&Purity | SDS-PAGE; > 95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | 2 to 20 ng/ml |
| Application Notes | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| Format | Lyophilized |
| Storage | -80°C; Lyophilized in PBS. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IL23 is composed of a subunit of the heterodimeric cytokine IL23 and the p40 subunit of interleukin 12 (IL12B). Interleukin-23 (IL-23) belongs to the IL-12 family and is produced by antigen presenting cells. IL-23 using IL12RB1 and IL-23R (specific for IL-23) can activate STAT and NF-kB pathways and stimulate the production of interferon-gamma. ). IL-23 is known to take a vital part in the inflammation process and is associated with auto immune diseases. However, unlike IL12, which acts primarily on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
References
Oppmann B.,et al.Immunity 13:715-725(2000).
Hirata Y.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Parham C.,et al.J. Immunol. 168:5699-5708(2002).
Pirhonen J.,et al.J. Immunol. 169:5673-5678(2002).
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