|Calculated MW||25 kDa, homodimer, nonglycosylated|
|Other Names||Transforming Growth Factor-beta3, TGFB3, ARVD, FLJ16571, TGF-beta 3.|
|Source||Human 293 cell expressed|
|Assay&Purity||SDS-PAGE; > 95%|
|Results||0.1 to 0.5 ng/ml|
|Application Notes||Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized from 50 mM sodium acetate, pH 4.5 and 350 mM NaCl.|
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Provided below are standard protocols that you may find useful for product applications.
Transforming growth factor betas (TGFβ) mediate many cell-cell interactions that occur during embryonic development. Three TGFβs have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. TGF-beta 3 influences pathogenesis and pulmonary development.
ten Dijke P.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4715-4719(1988).
Derynck R.,et al.EMBO J. 7:3737-3743(1988).
Madan A.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
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