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Human CellExp TNF-alpha, Human recombinant protein
Human Cellexp Human Recombinant TNF-alpha
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01375 |
|---|---|
| Calculated MW | 17 kDa, non-disulfide bonded homotrimer, glycosylated |
| Gene ID | 7124 |
|---|---|
| Gene Symbol | TNF |
| Other Names | TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2. |
| Gene Source | Human |
| Source | Human 293 cell expressed |
| Assay&Purity | SDS-PAGE; > 95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | < 0.9 ng/ml |
| Application Notes | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| Format | Lyophilized |
| Storage | -80°C; Lyophilized in PBS. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Tumor Necrosis Factor-α (TNF-α) is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. TNF is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.
References
Nedospasov S.A.,et al.Cold Spring Harb. Symp. Quant. Biol. 51:611-624(1986).
Pennica D.,et al.Nature 312:724-729(1984).
Shirai T.,et al.Nature 313:803-806(1985).
Nedwin G.E.,et al.Nucleic Acids Res. 13:6361-6373(1985).
Wang A.M.,et al.Science 228:149-154(1985).
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