Human CellExp TPO, Human recombinant protein
Human Cellexp Human Recombinant TPO
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P40225 |
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Calculated MW | 80 to 85 kDa, monomer, glycosylated |
Gene ID | 7066 |
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Gene Symbol | THPO |
Other Names | Megakaryocyte colony-stimulating factor, Myeloproliferative leukemia virus oncogene ligand, C-mpl ligand, ML, Megakaryocyte growth and development factor, MGDF, TPO, MKCSF, MPLLG, MGC163194, THPO. |
Gene Source | Human |
Source | Human 293 cell expressed |
Assay&Purity | SDS-PAGE; > 95% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Results | 0.5 to 5 ng/ml |
Application Notes | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
Format | Lyophilized |
Storage | -80°C; Lyophilized in PBS. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TPO (Thrombopoietin, also known as Mpl-ligand, MGDF), a glycoprotein hormone produced mainly by the liver and the kidney, stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets.
References
de Sauvage F.J.,et al.Nature 369:533-538(1994).
Bartley T.D.,et al.Cell 77:1117-1124(1994).
Foster D.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:13023-13027(1994).
Sohma Y.,et al.FEBS Lett. 353:57-61(1994).
Gurney A.L.,et al.Blood 85:981-988(1995).
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