|Calculated MW||80 to 85 kDa, monomer, glycosylated|
|Other Names||Megakaryocyte colony-stimulating factor, Myeloproliferative leukemia virus oncogene ligand, C-mpl ligand, ML, Megakaryocyte growth and development factor, MGDF, TPO, MKCSF, MPLLG, MGC163194, THPO.|
|Source||Human 293 cell expressed|
|Assay&Purity||SDS-PAGE; > 95%|
|Results||0.5 to 5 ng/ml|
|Application Notes||Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.|
|Storage||-80°C; Lyophilized in PBS.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TPO (Thrombopoietin, also known as Mpl-ligand, MGDF), a glycoprotein hormone produced mainly by the liver and the kidney, stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets.
de Sauvage F.J.,et al.Nature 369:533-538(1994).
Bartley T.D.,et al.Cell 77:1117-1124(1994).
Foster D.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:13023-13027(1994).
Sohma Y.,et al.FEBS Lett. 353:57-61(1994).
Gurney A.L.,et al.Blood 85:981-988(1995).
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