|Calculated MW||53.0-56.0 kDa|
|Other Names||GSK, Glycogen synthase kinase-3 (GSK-3)|
|Application Notes||Reconstitute to 1 mg/ml in PBS containing 15% glycerol. The solution should be stored at –70°C, stable for up to 3 months.|
|Storage||-70°C; Lyophilized from 2 mg/ml in 0.1 M NH4CO3|
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Provided below are standard protocols that you may find useful for product applications.
Glycogen synthase kinase-3 (GSK-3) is a serine/theronine kinase that was first characterized by its role in intermediary metabolism. In mammals, serine kinase is encoded by two related genes called GSK-3α (51 kDa) and GSK-3β (46 kDa). GSK-3 has been implicated in the regulation of the c-JuP-1 transcription factor and other intracellular signaling pathways.
Stambolic V.,et al.Biochem. J. 303:701-704(1994).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Lau K.F.,et al.Genomics 60:121-128(1999).
Rhoads A.R.,et al.Mol. Psychiatry 4:437-442(1999).
Boyle W.J.,et al.Cell 64:573-584(1991).
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