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GSK-3β, human recombinant protein
GSK, Glycogen synthase kinase-3 (GSK-3)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P49841 |
|---|---|
| Calculated MW | 53.0-56.0 kDa |
| Gene ID | 2932 |
|---|---|
| Gene Symbol | GSK3B |
| Other Names | GSK, Glycogen synthase kinase-3 (GSK-3) |
| Gene Source | Human |
| Source | E.coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Application Notes | Reconstitute to 1 mg/ml in PBS containing 15% glycerol. The solution should be stored at –70°C, stable for up to 3 months. |
| Format | Lyophilized powder |
| Storage | -70°C; Lyophilized from 2 mg/ml in 0.1 M NH4CO3 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glycogen synthase kinase-3 (GSK-3) is a serine/theronine kinase that was first characterized by its role in intermediary metabolism. In mammals, serine kinase is encoded by two related genes called GSK-3α (51 kDa) and GSK-3β (46 kDa). GSK-3 has been implicated in the regulation of the c-JuP-1 transcription factor and other intracellular signaling pathways.
References
Stambolic V.,et al.Biochem. J. 303:701-704(1994).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Lau K.F.,et al.Genomics 60:121-128(1999).
Rhoads A.R.,et al.Mol. Psychiatry 4:437-442(1999).
Boyle W.J.,et al.Cell 64:573-584(1991).
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