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>   home   >   Products   >   Proteins   >   Human CellExp IL-4 Rα, Human recombinant protein   

Human CellExp IL-4 Rα, Human recombinant protein

soluble IL-4 receptor alpha, CD124

     
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  • CITATIONS
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Product info
Primary Accession P24394
Calculated MW ~24 kDa
Additional Info
Gene ID 3566
Gene Symbol IL4RA
Other Names soluble IL-4 receptor alpha, CD124
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 HPLC;
Recombinant Yes
Sequence GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH
Target/Specificity IL-4 Rα
Application Notes Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to - 80°C
Format Lyophilized powder
Storage -20°C; Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS pH 7.0.
Citations (0)

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Background

IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc). The type I receptor contains in addition to the γc an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα. The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4Rα is a 209 amino acid protein which corresponds to the entire extracellular domain of IL- 4Rα.

References

Idzerda R.L.,et al.J. Exp. Med. 171:861-873(1990).
Galizzi J.-P.,et al.Int. Immunol. 2:669-675(1990).
Kruse S.,et al.Int. Immunol. 11:1965-1970(1999).
Loftus B.J.,et al.Genomics 60:295-308(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 165.00
$ 765.00
Cat# PBV10736r
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