Activin B, Human recombinant protein
Activin beta-B, Inhibin beta-2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P36896 |
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Calculated MW | 25.6 kDa |
Gene ID | 91 |
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Gene Symbol | ACVR1B |
Other Names | Activin beta-B, Inhibin beta-2 |
Gene Source | Human |
Source | (BTI-Tn-5B1-4) Hi-5 Insect cells |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | HPLC; |
Recombinant | Yes |
Sequence | GLECDGRTNL CCRQQFFIDF RLIGWNDWII APTGYYGNYC EGSCPAYLAG VPGSASSFHT AVVNQYRMRG LNPGTVNSCC IPTKLSTMSM LYFDDEYNIV KRDVPNMIVE ECGCA |
Target/Specificity | Activin B |
Application Notes | Centrifuge the vial prior to opening. Reconstitute in 10 mM Sodium citrate, pH 3.0 to a concentration of 0.5 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
Format | Lyophilized powder |
Storage | -20°C; Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Citrate, pH 3.0 and 5% Trehalose. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Activin B is a TGF-β family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.
References
ten Dijke P.,et al.Oncogene 8:2879-2887(1993).
Carcamo J.,et al.Mol. Cell. Biol. 14:3810-3821(1994).
Xu J.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:7957-7961(1994).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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