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AITRL, Human recombinant protein

Activation-induced TNFR member Ligand, TNFSF18, GITRL, TL-6

     
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Product info
Primary Accession Q9UNG2
Calculated MW 14.4 kDa
Additional Info
Gene ID 8995
Gene Symbol TNFSF18
Other Names Activation-induced TNFR member Ligand, TNFSF18, GITRL, TL-6
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 HPLC;
Recombinant Yes
Sequence METAKEPCMA KFGPLPSKWQ MASSEPPCVN KVSDWKLEIL QNGLYLIYGQ VAPNANYNDV APFEVRLYKN KDMIQTLTNK SKIQNVGGTY ELHVGDTIDL IFNSEHQVLK NNTYWGIILL ANPQFIS
Target/Specificity AITRL
Application Notes Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Format Lyophilized powder
Storage -20°C; Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Tris, pH 8.0.
Citations (0)

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Background

AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177 amino acids, including a 28 amino acid cytoplasmic region, a 21 amino acid transmembrane domain and a 128 amino acid extracellular domain. Recombinant human soluble AITRL is a 14.4 kDa protein, containing 127 amino acid residues corresponding to the extracellular domain of AITRL.

References

Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Gurney A.L.,et al.Curr. Biol. 9:215-218(1999).

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$ 185.00
$ 815.00
Cat# PBV10748r
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