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GDNF, murine recombinant protein

Glial-Derived Neurotrophic Factor, ATF-1

     
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Product info
Primary Accession P48540
Calculated MW 15.1 kDa
Additional Info
Gene ID 14573
Gene Symbol GDNF
Other Names Glial-Derived Neurotrophic Factor, ATF-1
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 HPLC;
Recombinant Yes
Sequence MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Target/Specificity GDNF
Application Notes Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Format Lyophilized powder
Storage -20°C; Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium citrate.
Citations (0)

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Background

GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional murine GDNF ligand is a disulfide-linked homodimer, of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.

References

Watabe K.,et al.J. Neurosci. Res. 41:279-290(1995).
Hellmich H.L.,et al.Mech. Dev. 54:95-105(1996).
Matsushita N.,et al.Gene 203:149-157(1997).
Wang F.-J.,et al.Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 30:375-381(1998).

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$ 210.00
$ 995.00
Cat# PBV10786r
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