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Gremlin-1, human recombinant protein
CKTSF1B1, DAND2, DRM, IHG-2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O70326 |
|---|---|
| Calculated MW | 18.3 kDa |
| Gene ID | 23892 |
|---|---|
| Gene Symbol | Grem1 |
| Other Names | CKTSF1B1, DAND2, DRM, IHG-2 |
| Gene Source | Human |
| Source | CHO cells |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Sequence | KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD |
| Target/Specificity | Gremlin-1 |
| Application Notes | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
| Format | Lyophilized powder |
| Storage | -20°C; Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.5 and 150 mM NaCl. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is an 18.3 kDa protein containing 160 amino acid residues.
References
Hsu D.R.,et al.Mol. Cell 1:673-683(1998).
Zhang Q.,et al.Cytogenet. Cell Genet. 89:242-251(2000).
Khokha M.K.,et al.Nat. Genet. 34:303-307(2003).
Pangas S.A.,et al.J. Biol. Chem. 279:32281-32286(2004).
Michos O.,et al.Development 131:3401-3410(2004).
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