|Calculated MW||12.3 kDa|
|Other Names||Mucosae-associated Epithelial Chemokine, CCL28, CCK-1|
|Sequence||SEAILPIASS CCTEVSHHIS RRLLERVNMC RIQRADGDCD LAAVILHVKR RRICVSPHNH TVKQWMKVQA AKKNGKGNVC HRKKHHGKRN SNRAHQGKHE TYGHKTPY|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.|
|Storage||-20°C; Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Acetic Acid.|
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Provided below are standard protocols that you may find useful for product applications.
MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.
Wang W.,et al.J. Biol. Chem. 275:22313-22323(2000).
Pan J.,et al.J. Immunol. 165:2943-2949(2000).
Zhang W.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Scanlon K.M.,et al.Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
Schmutz J.,et al.Nature 431:268-274(2004).
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