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UPK3A, human recombinant protein

Uroplakin 3A, UPK3, UPIII, Uroplakin III, UP3A

     
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Product info
Primary Accession O75631
Calculated MW 23.1 kDa
Additional Info
Gene ID 7380
Gene Symbol UPK3A
Other Names Uroplakin 3A, UPK3, UPIII, Uroplakin III, UP3A
Gene Source Human
Source E. Coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Sequence MGSSHHHHHH SSGLVPRGSH MGSHMVNLQP QLASVTFATN NPTLTTVALE KPLCMFDSKE ALTGTHEVYL YVLVDSAISR NASVQDSTNT PLGSTFLQTE GGRTGPYKAV AFDLIPCSDL PSLDAIGDVS KASQILNAYL VRVGANGTCL WDPNFQGLCN PPLSAATEYR FKYVLVNMST GLVEDQTLWS DPIRTNQLTP YSTIDTWPGR RSGG
Target/Specificity UPK3A
Format Liquid
Storage -20°C; Sterile filtered colorless solution of 0.25 mg/ml containing 20 mM Tris-HCl buffer (pH 8.0), 150 mM NaCl, 2 mM DTT and 20% glycerol.
Citations (0)

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Background

UPK3A is a member of the uroplakin-3 family. Uroplakins (UP) which are transmembrane proteins are important components of the urothelium that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both members of the "tetraspanin" family). All hold great luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic shares in their C-termini. UPK3A is an extremely specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Alterations in this gene are related to renal adysplasia.

References

Geall K.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Yuasa T.,et al.Jpn. J. Cancer Res. 89:879-882(1998).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Lobban E.D.,et al.Am. J. Pathol. 153:1957-1967(1998).

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$ 195.00
$ 595.00
Cat# PBV10818r-10
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