|Calculated MW||6.0 kDa|
|Other Names||H2 relaxin, RLN2|
|Sequence||A Chain: QLYSALANKC CHVGCTKRSL ARFC B Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.|
|Storage||-20°C; Sterile filtered through a 0.2 micron filter. Lyophilized with no additives|
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Provided below are standard protocols that you may find useful for product applications.
Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an “orphan” G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Recombinant Relaxin-2 is a nonglycosylated 6.0 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain.
Hudson P.,et al.EMBO J. 3:2333-2339(1984).
Humphray S.J.,et al.Nature 429:369-374(2004).
Gunnersen J.M.,et al.Mol. Cell. Endocrinol. 118:85-94(1996).
Garibay-Tupas J.L.,et al.J. Mol. Endocrinol. 23:355-365(1999).
Winslow J.W.,et al.Endocrinology 130:2660-2668(1992).
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