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Relaxin-2, human recombinant protein

H2 relaxin, RLN2

     
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Product info
Primary Accession P04090
Calculated MW 6.0 kDa
Additional Info
Gene ID 6019
Gene Symbol RLN2
Other Names H2 relaxin, RLN2
Gene Source Human
Source E. Coli
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 HPLC;
Recombinant Yes
Sequence A Chain: QLYSALANKC CHVGCTKRSL ARFC B Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS
Target/Specificity Relaxin-2
Application Notes Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Format Lyophilized powder
Storage -20°C; Sterile filtered through a 0.2 micron filter. Lyophilized with no additives
Citations (0)
citation

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Background

Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an “orphan” G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Recombinant Relaxin-2 is a nonglycosylated 6.0 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain.

References

Hudson P.,et al.EMBO J. 3:2333-2339(1984).
Humphray S.J.,et al.Nature 429:369-374(2004).
Gunnersen J.M.,et al.Mol. Cell. Endocrinol. 118:85-94(1996).
Garibay-Tupas J.L.,et al.J. Mol. Endocrinol. 23:355-365(1999).
Winslow J.W.,et al.Endocrinology 130:2660-2668(1992).

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Discontinued
Cat# PBV10824r-10
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