|Calculated MW||5.5 kDa|
|Other Names||H3 relaxin, Insulin-like peptide-7, INSL7|
|Sequence||A Chain: DVLAGLSSSC CKWGCSKSEI SSLC B Chain: RAAPYGVRLC GREFIRAVIF TCGGSRW|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.|
|Storage||-20°C; Sterile filtered through a 0.2 micron filter. Lyophilized with no additives|
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Provided below are standard protocols that you may find useful for product applications.
Relaxin-3 (H3 relaxin, Insulin-like peptide-7, INSL7) is a secreted protein structurally related to insulin, which is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as “somatostatin-like” or “angiotensin-like” peptide receptor, and also binds specifically to the LGR7 receptor, previously identified as an “orphan” G protein coupled receptor. Signaling by Relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intra cerebroventricular injections of Relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats. Recombinant Relaxin-3 is a 5.5 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 27 amino acid B-chain.
Holloway J.L.,et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
Kizawa H.,et al.Regul. Pept. 113:79-84(2003).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Sudo S.,et al.J. Biol. Chem. 278:7855-7862(2003).
Liu C.,et al.J. Biol. Chem. 278:50754-50764(2003).
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