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Human CellExp VEGF-C, human recombinant protein


Product info
Primary Accession P49767
Calculated MW The protein is fused with 6×His tag at the C-terminus, has a calculated MW of 15 kDa. The predicted N-terminus is Thr 103. DTT-reduced Protein migrates as 18-23 kDa due to glycosylation.
Additional Info
Gene ID 7424
Gene Symbol VEGF-C
Other Names VEGFC, Flt4-L, VRP
Gene Source Human
Source HEK 293 cells
Assay&Purity SDS-PAGE; ≥97%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity VEGF-C
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized powder
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Citations (0)

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Vascular endothelial growth factor C is also known as VEGFC, Flt4-L and VRP; it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs. Upon biosynthesis, VEGFC is secreted as a non-covalent momodimer in an anti-parallel fashion. VEGFC is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor D (VEGF-D). VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Overexpression of VEGF-C causes lymphatics to enlarge possibly facilitates metastasis.


Joukov V.,et al.EMBO J. 15:290-298(1996).
Joukov V.,et al.EMBO J. 15:1751-1751(1996).
Lee J.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:1988-1992(1996).
Fitz L.J.,et al.Oncogene 15:613-618(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 285.00
Cat# PBV10861r
(40 western blots)
Availability: 5-7days
Bulk Size
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