Tudor domain-containing protein 4 (hTDRD4, domain 30-139aa), human recombinant protein
RING finger protein 17, Tudor domain-containing protein 4, TDRD4, RNF17
|Calculated MW||14.6 kDa (110 aa + NT 6 x His-tag)|
|Other Names||RING finger protein 17, Tudor domain-containing protein 4, TDRD4, RNF17|
|Storage||-80°C; 1.0 mg/ml solution in 25 mM Tris (pH 8.0) buffer containing 20% glycerol.|
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Tudor domains are small protein structural motifs of about ~50 amino acids related to the “royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling. The Tudor domains recognize symmetric methylated arginine or methylated lysine residues. Tudor domain proteins act as an oncogene and play a very important role in HCC and colon cancer. TDRD is also involved in RISC complex and interacts with AEG-1 oncogene. The Tudor domain can bind to methylated arginine protein and promote tumor angiogenesis in human hepatocellular carcinoma, etc. TDRD4 is a candidate CT antigen expressed in a subset of liver cancers. The recombinant protein includes TDRD4 (domain 30-139 aa) with N-terminal His-tag.
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Dunham A.,et al.Nature 428:522-528(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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