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>   home   >   Products   >   Proteins   >   Nicotinamide N-Methyltransferase, Human recombinant protein (hNNMT)   

Nicotinamide N-Methyltransferase, Human recombinant protein (hNNMT)


Product info
Primary Accession P40261
Concentration 3.42
Calculated MW 31.7 kDa (263aa + NT 6xHis-tag)
Additional Info
Gene ID 4837
Gene Symbol NNMT
Other Names NNMT
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 N/A;
Recombinant Yes
Target/Specificity NNMT
Format Liquid
Storage -80°C; 3.42 mg/ml solution in 25 mM Tris (pH8.0) buffer containing 20% glycerol
Citations (0)

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N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.


Aksoy S.,et al.J. Biol. Chem. 269:14835-14840(1994).
Aksoy S.,et al.Genomics 29:555-561(1995).
Hubbard M.J.,et al.Electrophoresis 21:3785-3796(2000).
Choudhary C.,et al.Science 325:834-840(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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$ 195.00
$ 495.00
$ 2,950.00
Cat# PBV10886r
(40 western blots)
Availability: 5-7days
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