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>   home   >   Products   >   Proteins   >   Human CellExp PCSK9, murine recombinant protein   

Human CellExp PCSK9, murine recombinant protein

PCSK9, FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, Proprotein convertase subtilisin/kexin type 9

Product info
Primary Accession Q80W65
Calculated MW This protein is fused with 6×His tag at the N-terminus, has a calculated MW of 72 kDa. The predicted N-terminus is Gln 35. DTT-reduced Protein migrates as 20 kDa and 64 kDa due to glycosylation.
Additional Info
Gene ID 100102
Gene Symbol PCSK9
Other Names PCSK9, FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, Proprotein convertase subtilisin/kexin type 9
Gene Source Mouse
Source HEK 293 cells
Assay&Purity SDS-PAGE; ≥97%
Assay2&Purity2 N/A;
Recombinant Yes
Target/Specificity PCSK9
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 100 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized powder
Storage -20°C; Sterile filtered through a 0.22 micron filter. Lyophilized from 1 x PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Citations (0)

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Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).


Chiang L.W.,et al.Patent number WO0157081, 09-AUG-2001.
Maxwell K.N.,et al.J. Lipid Res. 44:2109-2119(2003).
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Seidah N.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:928-933(2003).

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$ 285.00
Cat# PBV10891r
(40 western blots)
Availability: 5-7days
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