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Human CellExp Cathepsin S, human recombinant protein

Cathepsin S, CTSS

Product info
Primary Accession P25774
Concentration 0.2 µM
Calculated MW ~ 37 kDa
Additional Info
Gene ID 1520
Gene Symbol CTSS
Other Names Cathepsin S, CTSS
Gene Source Human
Source HEK 293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 SEC-HPLC; ≥95%
Recombinant Yes
Results >1000 mU (1U = 1 µmole/min/mg) .
Target/Specificity Cathepsin S
Format Liquid
Storage -80°C; A 0.2 µM filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
Citations (0)

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Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease (AD) and Down Syndrome (DS).


Shi G.-P.,et al.J. Biol. Chem. 267:7258-7262(1992).
Wiederanders B.,et al.J. Biol. Chem. 267:13708-13713(1992).
Wiederanders B.,et al.Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
Shi G.-P.,et al.J. Biol. Chem. 269:11530-11536(1994).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 255.00
$ 940.00
$ 7,295.00
Cat# PBV10902r
(40 western blots)
Availability: 5-7days
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