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Human CellExp CD71 / TFRC / TFR, human recombinant protein

CD71, TFRC, TFR, sTfR, TfR1, Trfr, T9, p90

     
  • SPECIFICATION
  • CITATIONS
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Product info
Primary Accession P02786
Calculated MW This protein is fused with 6×His tag at the N-terminus, has a calculated MW of 76 kDa. The predicted N-terminus is Cys 89. DTT-reduced Protein migrates as 80-85 kDa due to glycosylation.
Additional Info
Gene ID 7037
Gene Symbol TFRC
Other Names CD71, TFRC, TFR, sTfR, TfR1, Trfr, T9, p90
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥92%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its binding ability in a functional ELISA. Immobilized rhCD71/TFR at 10 µg/ml (100 µl/well) can bind human Transferrin. The EC50 of human Transferrin is 6.4 ng/ml.
Target/Specificity CD71 /TFRC /TFR
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Citations (0)
citation

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Background

CD antigen CD71 is also known as Transferrin receptor protein 1, TfR, sTfR, p90, TfR1, Trfr, which belongs to the peptidase M28 family and M28B subfamily. CD71 /TFR contains one PA (protease associated) domain. CD71 / TfR1 is required for iron delivery from transferrin to cells. CD71 is a potential new target in cases of human leukemia & lymphoma. CD71 /TFRC / TfR has been shown to interact with GABARAP and HFE.

References

Schneider C.,et al.Nature 311:675-678(1984).
McClelland A.,et al.Cell 39:267-274(1984).
Evans P.,et al.Gene 199:123-131(1997).
Wheeler D.L.,et al.Thesis (1999), University of Iowa, United States.
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# PBV10904r-10
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