Proteinase 3 (PR3), Human Neutrophil recombinant protein
AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen
|Calculated MW||29 kDa|
|Other Names||AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen|
|Storage||-80°C; Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl.|
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Provided below are standard protocols that you may find useful for product applications.
Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by alpha1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation.
Labbaye C.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:9253-9256(1991).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zimmer M.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:8215-8219(1992).
Sturrock A.B.,et al.J. Biol. Chem. 267:21193-21199(1992).
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