Proteinase 3 (PR3), Human Neutrophil recombinant protein
AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P24158 |
---|---|
Calculated MW | 29 kDa |
Gene ID | 5657 |
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Gene Symbol | AGP7 |
Other Names | AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen |
Gene Source | Human |
Source | Human Neutrophils |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | N/A; |
Recombinant | No |
Target/Specificity | AGP7 |
Format | Frozen |
Storage | -80°C; Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by alpha1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation.
References
Labbaye C.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:9253-9256(1991).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zimmer M.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:8215-8219(1992).
Sturrock A.B.,et al.J. Biol. Chem. 267:21193-21199(1992).
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