Alpha 1 Antitrypsin, Human Plasma recombinant protein
Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI
|Calculated MW||52 kDa|
|Gene Symbol||Serpin A1|
|Other Names||Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI|
|Results||≥ 5.0 IU/mg|
|Application Notes||In water or aqueous buffer|
|Storage||-20°C; Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.|
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Provided below are standard protocols that you may find useful for product applications.
Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammation.
Bollen A.,et al.DNA 2:255-264(1983).
Long G.L.,et al.Biochemistry 23:4828-4837(1984).
Rosenberg S.,et al.Nature 312:77-80(1984).
Ciliberto G.,et al.Cell 41:531-540(1985).
Nukiwa T.,et al.J. Biol. Chem. 261:15989-15994(1986).
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