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Alpha 1 Antitrypsin, Human Plasma recombinant protein
Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01009 |
|---|---|
| Calculated MW | 52 kDa |
| Gene ID | 5265 |
|---|---|
| Gene Symbol | Serpin A1 |
| Other Names | Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI |
| Gene Source | Human |
| Source | Human Plasma |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | No |
| Results | ≥ 5.0 IU/mg |
| Target/Specificity | Serpin A1 |
| Application Notes | In water or aqueous buffer |
| Format | Lyophilized |
| Storage | -20°C; Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammation.
References
Bollen A.,et al.DNA 2:255-264(1983).
Long G.L.,et al.Biochemistry 23:4828-4837(1984).
Rosenberg S.,et al.Nature 312:77-80(1984).
Ciliberto G.,et al.Cell 41:531-540(1985).
Nukiwa T.,et al.J. Biol. Chem. 261:15989-15994(1986).
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