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Alpha 1 Antitrypsin, Human Plasma recombinant protein

Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI

     
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  • CITATIONS
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Product info
Primary Accession P01009
Calculated MW 52 kDa
Additional Info
Gene ID 5265
Gene Symbol Serpin A1
Other Names Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI
Gene Source Human
Source Human Plasma
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Results ≥ 5.0 IU/mg
Target/Specificity Serpin A1
Application Notes In water or aqueous buffer
Format Lyophilized
Storage -20°C; Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.
Citations (0)

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Background

Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammation.

References

Bollen A.,et al.DNA 2:255-264(1983).
Long G.L.,et al.Biochemistry 23:4828-4837(1984).
Rosenberg S.,et al.Nature 312:77-80(1984).
Ciliberto G.,et al.Cell 41:531-540(1985).
Nukiwa T.,et al.J. Biol. Chem. 261:15989-15994(1986).

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$ 80.00
Cat# PBV10918r
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