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>   home   >   Products   >   Proteins   >   Alpha 2 Macroglobulin, Human Plasma, Fast Form recombinant protein   

Alpha 2 Macroglobulin, Human Plasma, Fast Form recombinant protein

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5, FWP007

Product info
Primary Accession P01023
Calculated MW 725 kDa (Homotetramer, Subunit size: 180 kDa)
Additional Info
Gene ID 2
Gene Symbol A2M
Other Names C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5, FWP007
Gene Source Human
Source Human Plasma
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Target/Specificity Alpha 2 Macroglobulin
Application Notes In water or aqueous buffer
Format Lyophilized
Storage -20°C; Lyophilized from 100 mM Na Phosphate, pH 7.2.
Citations (0)

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Alpha 2 Macroglobulin (A2M) is a plasma protease inhibitor which has been shown to exist in two forms. The Slow Form of A2M (S-A2M) is the form which possesses the ability to bind and inhibit proteases by a “trap” method. The Fast Form of A2M (F-A2M) is generated when S-A2M undergoes a conformational change due to either entrapment of a protease in the A2M bait region, or chemical cleavage of an internal thiol ester bond located near the bait region. F-A2M does not possess the ability to bind and inhibit protease activity. F-A2M is rapidly taken up by the liver, with a half-life of 2-4 minutes. In vivo, F-A2M typically represents only 0.17–0.7% of the total A2M in blood plasma of adults. The F-A2M plasma concentration is, however, increased in many disease states including pancreatitis, multiple sclerosis and sepsis. F-A2M has also been implicated in the inhibition of amyloid formation associated with Alzheimer’s disease and spongiform encephalopathy.


Kan C.-C.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:2282-2286(1985).
Lin V.K.,et al.Prostate 63:299-308(2005).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherer S.E.,et al.Nature 440:346-351(2006).

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$ 175.00
Cat# PBV10921r
(40 western blots)
Availability: 5-7days
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