Alpha 2 Macroglobulin, Human Plasma, Fast Form recombinant protein
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5, FWP007
|Calculated MW||725 kDa (Homotetramer, Subunit size: 180 kDa)|
|Other Names||C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5, FWP007|
|Target/Specificity||Alpha 2 Macroglobulin|
|Application Notes||In water or aqueous buffer|
|Storage||-20°C; Lyophilized from 100 mM Na Phosphate, pH 7.2.|
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Provided below are standard protocols that you may find useful for product applications.
Alpha 2 Macroglobulin (A2M) is a plasma protease inhibitor which has been shown to exist in two forms. The Slow Form of A2M (S-A2M) is the form which possesses the ability to bind and inhibit proteases by a “trap” method. The Fast Form of A2M (F-A2M) is generated when S-A2M undergoes a conformational change due to either entrapment of a protease in the A2M bait region, or chemical cleavage of an internal thiol ester bond located near the bait region. F-A2M does not possess the ability to bind and inhibit protease activity. F-A2M is rapidly taken up by the liver, with a half-life of 2-4 minutes. In vivo, F-A2M typically represents only 0.17–0.7% of the total A2M in blood plasma of adults. The F-A2M plasma concentration is, however, increased in many disease states including pancreatitis, multiple sclerosis and sepsis. F-A2M has also been implicated in the inhibition of amyloid formation associated with Alzheimer’s disease and spongiform encephalopathy.
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Scherer S.E.,et al.Nature 440:346-351(2006).
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