Kininogen, LMW, Human Plasma recombinant protein
Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight Kininogen, Williams-Fit
|Calculated MW||65 kDa|
|Other Names||Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight Kininogen, Williams-Fitzgerald-Flaujeac factor, BDK, KNG, Kininogen-1 heavy chain, T-kinin, Bradykinin, Lysyl-bradykinin, Kininogen-1 light chain, Low molecular weight growth-promoting factor|
|Application Notes||In water or aqueous buffer|
|Storage||-20°C; Lyophilized from 10 mM Na acetate, pH 5.5 with 200 mM NaCI|
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Provided below are standard protocols that you may find useful for product applications.
LMW Kininogen is involved in blood pressure regulation since it is an endogenous protein substrate for tissue kallikrein. Proteolytic cleavage by kallikrein releases vasoactive bradykinin from LMW kininogen. In addition, LMW kininogen, like HMW kininogen, is a major extracellular cysteine protease inhibitor.
Ohkubo I.,et al.Biochemistry 23:5691-5697(1984).
Takagaki Y.,et al.J. Biol. Chem. 260:8601-8609(1985).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Muzny D.M.,et al.Nature 440:1194-1198(2006).
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