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Kininogen, LMW, Human Plasma recombinant protein

Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight Kininogen, Williams-Fit

     
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Product info
Primary Accession P01042
Calculated MW 65 kDa
Additional Info
Gene ID 3827
Gene Symbol KNG1
Other Names Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight Kininogen, Williams-Fitzgerald-Flaujeac factor, BDK, KNG, Kininogen-1 heavy chain, T-kinin, Bradykinin, Lysyl-bradykinin, Kininogen-1 light chain, Low molecular weight growth-promoting factor
Gene Source Human
Source Human Plasma
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Target/Specificity Kininogen
Application Notes In water or aqueous buffer
Format Lyophilized
Storage -20°C; Lyophilized from 10 mM Na acetate, pH 5.5 with 200 mM NaCI
Citations (0)

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Background

LMW Kininogen is involved in blood pressure regulation since it is an endogenous protein substrate for tissue kallikrein. Proteolytic cleavage by kallikrein releases vasoactive bradykinin from LMW kininogen. In addition, LMW kininogen, like HMW kininogen, is a major extracellular cysteine protease inhibitor.

References

Ohkubo I.,et al.Biochemistry 23:5691-5697(1984).
Takagaki Y.,et al.J. Biol. Chem. 260:8601-8609(1985).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Muzny D.M.,et al.Nature 440:1194-1198(2006).

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$ 125.00
Cat# PBV10925r
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